Targeted Nanocarrier Systems for Delivery of Actives Across Biological Membranes
AssigneeAccess Pharmaceuticals, Inc.
InventorsDavid P. Nowotnik, Ryszard Zarzycki, Paul Sood, N.Rao Ummaneni
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Abstract
Disclosed herein are nanoparticle, micelle and/or liposome compositions, each comprising a therapeutic agent encapsulated in one or more polymer(s), wherein a vitamin B12 or a derivative thereof is attached to the one or more polymer(s) via a linker group, as well as methods for making and using same.
Claims23
A nanoparticle comprising a therapeutic agent encapsulated by one or more polymer(s) to which vitamin B12 or a derivative thereof is attached to the at least one or more polymer(s) via a linker group.
A micelle comprising a therapeutic agent encapsulated by the micelle and vitamin B12 or a derivative thereof attached to the micelle as a targeting agent.
A method for preparing a nanoparticle composition comprising admixing a therapeutic agent and at least one polymer to which vitamin B12 or a derivative thereof is attached by a linker group in a suitable solvent and optionally, wherein the ratio of the polymer to the therapeutic agent is in a range selected from the group of 1 to 15%, 1 to 40%, 5 to 50%, 5 to 40%, 5 to 30%, 10 to 35%, or 10 to 30%.
Dependencies are inferred from the claim text.