Immunomodulating Nanoparticulate Composition
OwnerSebastian Fuchs, Conrad Coester +3inventors
InventorsSebastian Fuchs, Conrad Coester, Heidrun Gehlen, John Klier, Gerhard Winter
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Abstract
The present invention relates to a preferably nebulizable pharmaceutical composition comprising a pharmaceutically acceptable protein-based nanocarrier preferably in the size range 150 to 300 nm and a preventative or therapeutic amount of an active agent for use in the prevention and/or treatment of an allergic and/or inflammatory disease of the lower airways in a mammal. Preferably, the active agent is a CpG oligodeoxynucleotide (CpG-ODN), and preferably the composition exhibits a prolonged clinical effect.
Claims17
A pharmaceutical composition comprising a pharmaceutically acceptable polymerized protein-based nanocarrier and a preventative or therapeutic amount of an active agent,
- for use in the prevention and/or treatment of an allergic and/or inflammatory disease of the lower airways in a mammal,
- wherein the active agent is an oligonucleotide and/or an oligodeoxynucleotide (ODN) which is effective for use in the prevention and/or treatment of an allergic and/or inflammatory disease of the lower airways,
- wherein the ODN is selected from the group consisting of guanidine phosphodiester cytosine (CpG) ODN class A, class B and/or class C,
- and wherein the active agent is coupled to the polymerized protein-based nanoparticle in a manner wherein the active agent maintains its preventive and/or therapeutic activity.
Dependencies are inferred from the claim text.