Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen as diagnostic and therapeutic tools for prostate cancer
AssigneeUniversitatsklinikum Freiburg
InventorsUrsula Elsässer-Beile, Philipp Wolf, Dorothee Gierschner, Patrick Bühler, Ulrich Wetterauer
Life of this patent
Estimating the term…
Abstract
Isolated monoclonal antibodies or an antigen binding portion thereof which bind to prostate specific membrane antigen in its native form occurring on the surface of tumor cells characterized in that it is linked to a label or a cytotoxic agent or constructed as a part of a bispecific antibody or a recombinant diabody.
Claims17
An antigen binding portion of an isolated monoclonal antibody which
- a) binds to prostate specific membrane antigen in its native form occurring on the surface of tumor cells
- b) can be internalized by a tumor cell,
- c) binds strongly to LNCAP cells but not or only minimally to cells which lack expression of prostate specific membrane antigen,
- d) is linked to a label or a cytotoxic agent,
- e) comprises an amino acid sequence of at least 10 consecutive amino acids of SEQ ID NO:10.
An antigen binding portion of an isolated monoclonal antibody which
- a) binds to prostate specific membrane antigen in its native form occurring on the surface of tumor cells,
- b) can be internalized by a tumor cell,
- c) binds strongly to LNCAP cells but not or only minimally to cells which lack expression of prostate specific membrane antigen,
- d) is linked to a label or a cytotoxic agent, and
- e) comprises an amino acid sequence of at least 10 consecutive amino acids of SEQ ID NO:1.
An antigen binding portion of an isolated monoclonal antibody which
- a) binds to prostate specific membrane antigen in its native form occurring on the surface of tumor cells,
- b) can be internalized by a tumor cell,
- c) binds strongly to LNCAP cells but not or only minimally to cells which lack expression of prostate specific membrane antigen,
- d) is linked to a label or a cytotoxic agent, and
- e) comprises an amino acid sequence of at least 10 consecutive amino acids of SEQ ID NO:20.
An antigen binding portion of an isolated monoclonal antibody which
- a) binds to prostate specific membrane antigen in its native form occurring on the surface of tumor cells,
- b) can be internalized by a tumor cell,
- c) binds strongly to LNCAP cells but not or only minimally to cells which lack expression of prostate specific membrane antigen,
- d) is linked to a label or a cytotoxic agent, and
- e) comprises an amino acid sequence of at least 10 consecutive amino acids of SEQ ID NO:22.
Dependencies are inferred from the claim text.