Fragile x mental retardation protein (fmrp), compositions, and methods related thereto
AssigneeEmory University
InventorsGary Bassell, Stephen Warren, Christina Gross
Life of this patent
Estimating the term…
Abstract
The invention relates to fragile X mental retardation protein (FMKP), compositions, and methods related thereto. In certain embodiments, the invention relates to treating a neurological disorder by administering a P13K antagonist to a subject in need thereof. In other embodiments, the invention relates to methods of diagnosing neurological disorders.
Claims28
A method of treating or preventing a disease related to fragile X mental retardation protein (FMRP) comprising administering a PI3K antagonist to a subject at risk of, exhibiting symptoms of , or diagnosed with the disease.
A method of treating synapse defects in the brain comprising administering a PI3K antagonist to a subject.
A method of diagnosing a disease related to fragile X mental retardation protein (FMRP) comprising assaying a sample from a subject for excessive PI3K or PI3K activity and correlating excessive PI3K or PI3K activity to a disease related to FMRP.
The method of claim 29, wherein assaying comprises moving the sample through separation medium and detecting PI3K, p85, or p110 subunit, phosphatidylinositol 3-phosphate, mRNA encoding PI3K, p85, or p110, or PI3K activity.
Dependencies are inferred from the claim text.