Ox2 Receptor Homologs
AssigneesMedical Research Council, Schering Corporation
InventorsA. Neil Barclay, Marion H. Brown, Daniel M. Gorman, Lewis L. Lanier, Gavin J. Wright, Holly Cherwinski, Joseph H. Phillips, Robert M. Hoek, Jonathan D. Sedgwick
Life of this patent
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Abstract
Nucleic acids encoding mammalian, e.g., primate, receptors, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
Claims12
A method of treating a patient for rheumatoid arthritis comprising administering to the patient an OX2R-binding antibody or an antigen-binding fragment thereof, comprising an antigen binding site from a substantially pure or recombinant antibody, wherein the antibody specifically binds to an antigen formed by the mature amino acid sequence set forth in SEQ ID NO:20, and wherein the antibody or antigen-binding fragment thereof has agonist activity for the receptor upon binding.
A method of treating a patient for multiple sclerosis comprising administering to the patient an OX2R-binding antibody or an antigen-binding fragment thereof, comprising an antigen binding site from a substantially pure or recombinant antibody, wherein the antibody specifically binds to an antigen formed by the mature amino acid sequence set forth in SEQ ID NO:20, and wherein the antibody or antigen-binding fragment thereof has agonist activity for the receptor upon binding.
An isolated OX2R-binding antibody or an antigen-binding fragment thereof, comprising an antigen binding site from a substantially pure or recombinant antibody, wherein the antibody specifically binds to an antigen formed by the mature amino acid sequence set forth in SEQ ID NO:20, and wherein the antibody or antigen-binding fragment thereof has agonist activity for the receptor upon binding.
Dependencies are inferred from the claim text.