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US 2012/0230990 A1Published application
Humanized antibodies against human il-22ra
AssigneeMerck Serono SA
InventorsRoland Beckmann, Caroline Johnson-Leger
Life of this patent
Estimating the term…
Abstract
The invention relates to humanized antibodies against human IL-22RA and to their use in the treatment of psoriasis and other immune-mediated diseases such as psoriatic arthritis and atopic dermatitis.
Claims15
1-19. (canceled)
A humanized antibody that binds to human IL-22RA which comprises:
- a) a heavy chain variable domain comprising H-CDR1, H-CDR2, and H-CDR3 consisting of amino acid sequences of SEQ ID NOs:
- 1, 2 and 3, respectively;
- and
- b) a light chain variable domain comprising L-CDR1, L-CDR2, and L-CDR3 consisting of amino acid sequences of SEQ ID NOs:
- 4, 5 and 6, respectively, or consisting of amino acid sequences of SEQ ID NOs:
- 4, 5 and 7, respectively.
3 more elements
A humanized antibody that binds to human IL-22RA, said humanized antibody:
- a) comprising a heavy chain comprising SEQ ID NO:
- 20 and a light chain comprising SEQ ID NO:
- 21;
- or
- b) comprising a heavy chain consisting of SEQ ID NO:
- 20 and a light chain consisting of SEQ ID NO:
- 21.
4 more elements
Dependencies are inferred from the claim text.