Antibody targeting osteoclast-related protein siglec-15
AssigneeDaiichi Sankyo Company, Limited
InventorsYoshiharu Hiruma, Eisuke Tsuda
Life of this patent
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Abstract
To provide a method of detecting abnormal bone metabolism by using a gene strongly expressed in an osteoclast; a method of screening a compound having a therapeutic and/or preventive effect on abnormal bone metabolism; and a pharmaceutical composition for treating and/or preventing abnormal bone metabolism. Provision of a method of detecting abnormal bone metabolism by using the expression of human Siglec-15 gene as an index; a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation; and the like.
Claims29
A method of treating or preventing abnormal bone metabolism comprising administering an antibody or a functional fragment of the antibody which binds one or more polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 or SEQ ID NO:
- 4, wherein said antibody or functional fragment of the antibody inhibits osteoclast formation and/or osteoclastic bone resorption.
A method for inhibiting osteoclast formation and/or osteoclast bone resorption comprising administering an antibody or functional fragment of the antibody which binds one or more polypeptides selected from the group consisting of SEQ ID NO:
- 2 or SEQ ID NO:
- 4.
A method for inhibiting osteoclast differentiation, the method comprising administering an antibody or a functional fragment thereof which specifically binds to an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 and SEQ ID NO:
- 4.
A method for inhibiting bone resorption, thereby treating or preventing abnormal bone metabolism, comprising administering an antibody or a functional fragment thereof which specifically binds to one or more polypeptides selected from the group consisting of SEQ ID NO:
- 2 and SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.