Humanized anti-factor d antibodies and uses thereof
AssigneeGenentech, Inc.
InventorsLING-LING AN, SEK CHUNG FUNG, ROBERT F. KELLEY, HENRY B. LOWMAN, SANJAYA SINGH, HERREN WU
Life of this patent
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Abstract
The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
Claims24
1-7. (canceled)
A humanized anti-Factor D antibody comprising the variable domain sequence of SEQ ID NO:
- 5 and the variable domain sequence in SEQ ID NO:
- 6.
A humanized anti-Factor D antibody comprising the variable domain sequence of SEQ ID NO:
- 7 and the variable domain sequence in SEQ ID NO:
- 8.
A humanized anti-Factor D antibody comprising the variable domain sequence of SEQ ID NO:
- 9 and the variable domain sequence in SEQ ID NO:
- 10.
A humanized anti-Factor D antibody comprising the variable domain sequence of SEQ ID NO:
- 11 and the variable domain sequence in SEQ ID NO:
- 12.
A humanized anti-Factor D antibody having a variable light chain comprising a CDR-L1 having the sequence of SEQ ID NO:
- 16;
- a CDR-L2 having the sequence of SEQ ID NO:
- 17, 21, or 23, and a CDR-L3 having the sequence of SEQ ID NO:
- 18, 22 or 24.
A humanized anti-Factor D antibody having a variable heavy chain comprising a CDR-H1 having the sequence of SEQ ID NO:
- 13 or 25;
- a CDR-H2 having the sequence of SEQ ID NO:
- 14;
- and a CDR-H3 having the sequence of SEQ ID NO:
- 15 or 20.
14-19. (canceled)
21-22. (canceled)
(canceled)
(canceled)
(canceled)
33-34. (canceled)
An antibody which competes with murine antibody 166-32 and/or humanized anti-Factor D antibody clone #56, #111, #250 or #416 and/or an antibody comprising variable domain or HVR sequences of humanized anti-Factor D antibody clone #56, #111, #250 or #416.
An antibody which binds to the same epitope as murine antibody 166-32 and/or humanized anti-Factor D antibody clone #56, #111, #250 or #416 and/or an antibody comprising variable domain or HVR sequences of humanized anti-Factor D antibody clone #56, #111, #250 or #416.
Dependencies are inferred from the claim text.