NOGO Receptor Binding Protein
AssigneeBiogen Idec MA Inc.
InventorsSha MI, John McCoy, R. Blake Pepinsky, Daniel H.S. Lee
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Abstract
The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.
Claims26
An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide wherein:
- (a) the polypeptide comprises at least one of (i) an Sp35 LRR domain, (ii) an Sp35 basic region C-terminal to the LRR domain, and (iii) an Sp35 immunoglobulin (Ig) domain C-terminal to the basic region;
- and (b) the polypeptide lacks a transmembrane domain.
2-10. (canceled)
14-30. (canceled)
A method of decreasing inhibition of axonal growth of a central nervous system (CNS) neuron, comprising contacting the neuron with an effective amount of an Sp35 antagonist.
(canceled)
A method of treating a CNS disease, disorder or injury in a mammal, comprising administering to the mammal a therapeutically effective amount of an Sp35 antagonist.
(canceled)
37-44. (canceled)
46-50. (canceled)
A method of promoting survival of a neuron at risk of dying, comprising contacting the neuron with an effective amount of an Sp35 antagonist.
55-57. (canceled)
Dependencies are inferred from the claim text.