Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer
AssigneeImmunomedics, Inc.
InventorsDavid M. GOLDENBERG, Hans J. HANSEN
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Abstract
Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases are disclosed, using multispecific antagonists that target at least two different markers. The different targets are proinflammatory effectors of the innate immune system. The multispecific antagonists can be used to treat sepsis or septic shock.
Claims26
1-18. (canceled)
A method of treating sepsis or septic shock, comprising administering to a patient that has been diagnosed with sepsis or septic shock a therapeutic composition comprising a therapeutically effective amount of a multispecific antagonist that reacts specifically with at least two different targets on a cell, wherein a first target is MIF and a second target is selected from the group consisting of a second proinflammatory effector cytokine, a proinflammatory effector chemokine, a proinflammatory effector receptor, a coagulation factor, a complement factor, or a complement regulatory protein.
Dependencies are inferred from the claim text.