Crystalline forms of n-(tert-butoxycarbonyl)-3-methyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-l-prolinamide
AssigneeBristol-Myers Squibb Company
InventorsRobert Kevin Perrone, Anne I. Song, Chenchi Wang, William Ying
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Abstract
The present disclosure generally relates to crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide. The present disclosure also generally relates to a pharmaceutical composition comprising one or more of the crystalline forms, as well of methods of using the crystalline forms in the treatment of Hepatitis C virus (HCV) and methods for obtaining such crystalline forms.
Claims11
Form TIF-1/2 of
Form TIF-1/2 of
- with characteristic peaks in the powder X-Ray diffraction pattern at values of two theta of 7.3±0.1, 9.1±0.1, 10.0±0.1, 10.6±0.1, 11.1±0.1, 12.3±0.1, 15.6±0.1, 20.1±0.1, 20.9±0.1, and 27.8±0.1 at a temperature between about 20° C. and about 25° C.
Form TIF-1/2 of
- characterized by one or more of the following:
- a) characteristic peaks in the powder X-Ray diffraction pattern at values of two theta of 7.3±0.1, 9.1±0.1, 10.0±0.1, 10.6±0.1, 11.1±0.1, 12.3±0.1, 15.6±0.1, 20.1±0.1, 20.9±0.1, and 27.8±0.1 at a temperature between about 20° C. and about 25° C.;
- and/or
- c) a first endotherm related to the melt with onset typically in the range of 140-145° C., followed by decomposition.
Substantially pure Form TIF-1/2 of
A pharmaceutical composition comprising Form TIF-1/2 of
- and a pharmaceutically acceptable carrier or diluent.
A pharmaceutical composition comprising Form TIF-1/2 of
- in combination with at least one additional compound having anti-HCV activity.
A method of treating HCV infection in a mammal comprising administering to the mammal a therapeutically-effective amount of Form TIF-1/2 of
Dependencies are inferred from the claim text.