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AssigneesHealth and Human Services, The Government of the United States of America represented by the Sectary of the Department of
InventorsJeffrey Schlom, Claudia M. Palena, Andrei P. Kozlov, Kwong-yok Tsang
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It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
A poxyiral vector encoding a Brachyury polypeptide, wherein the Brachyury polypeptide comprises an amino acid sequence at least 95% identical to the amino acid sequence set forth in SEQ ID NO:
A composition comprising a first recombinant poxvirus which has incorporated into a viral genome or infectable portion thereof a nucleic acid encoding an amino acid sequence at least 95% identical to SEQ ID NO:
A method of confirming the diagnosis of a tumor in a subject, or determining the prognosis of the tumor in the subject, comprising
Dependencies are inferred from the claim text.