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US 2012/0230944 A1Published application
Stabilization and storage of biological pharmaceutical compositions
AssigneesThe University of North Carolina at Charlotte, The Charlotte-Mecklenburg Hospital Authority, Monash University
InventorsGloria Elliott, Douglas MacFarlane, David M. Foureau, Iain McKillop
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Abstract
The present invention relates to compositions and methods for the preparation, stabilization, and/or storage of active agents, particularly therapeutic proteins and polypeptides such as Interleukin-2.
Claims22
A parenterally injectable pharmaceutical composition comprising:
- (a) from 0.01 to 50 weight percent choline dihydrogen phosphate;
- (b from 0 to 50 weight percent of a base;
- (c) at least 50 weight percent water;
- (d) from 0.01 to 10 weight percent active compound selected from the group consisting of Interleukin-2, gelsolin, antibodies, erythropoietin, interferon, human growth hormone, folicle stimulating hormone, and granulocyte colony stimulating factor;
- and
- (e) from 0 to 50 weight percent of at least one compatible osmolyte;
- (f) said composition having a pH of from 6 or 6.5 up to 7.5 or 8.
4 more elements
Dependencies are inferred from the claim text.