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AssigneeSkinMedica, Inc.
InventorsGail K. Naughton, David L. Horwitz, Mark A. Applegate, Joan Zeltinger, Jonathan N. Mansbridge, Andreas Kern, Lee K. Landeen, Anthony Ratcliffe, R. Emmett Pinney
Estimating the term…
Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
-78. (canceled)
A method of making a composition, comprising:
A conditioned medium comprising VEGF, wherein the medium is produced by inoculating stromal cells into a nutrient medium sufficient to meet the nutritional needs required to grow the cells in vitro, culturing the cells so that a conditioned medium is formed, wherein the conditioned medium comprises at least 3.2 ng/ml VEGF, and removing the conditioned medium from the cultured cells.
A cosmeceutical composition comprising:
Dependencies are inferred from the claim text.