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US 2012/0230914 A1Published application
Labeling compound for pet
AssigneeRiken
InventorsYasuyoshi Watanabe, Hirotaka Onoe, Kayo Takahashi, Masaaki Suzuki, Hisashi Doi, Takamitsu Hosoya
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Abstract
A labeling compound of the present invention includes a structure represented by formula (1) wherein X1 is 11CH3, CH218F, CF218F, 18F, 76Br or 124I, X2 is CN or NO2, and R is any one of groups represented by or a structure represented by formula (2) wherein X3 is CH3, CH2F, CF3, F, Br or I, and R is defined equally as in the formula (1). This allows realizing a labeling compound for PET, capable of quantifying aromatase with high accuracy.
Claims13
A compound, comprising
- a structure represented by formula (1)
- wherein X1 is 11CH3, CH218F, CF218F, 18F, 76Br or 124I, X2 is CN or NO2, and R is any one of groups represented by
- or
- a structure represented by formula (2)
- wherein X3 is CH3, CH2F, CF3, F, Br or I, and R is defined equally as in the formula (1).
2 more elements
A compound, comprising a structure represented by formula (1′)
- wherein X1 is CH3 or CH2F.
A compound, comprising
- a structure represented by formula (3)
- wherein X2 is CN or NO2, X4 is —CH2X5, —CF2X5, —SnR13, —B(OH)2, —BF3.K, —B(OR2)(OR3) or
- wherein A is a bivalent hydrocarbon group, and X5 is a leaving group selected from Cl, Br, I, —OSO2CH3, —OSO2C6H4(4-CH3) and —OSO2CF3, R1, R2, and R3 are independently an alkyl group having 1-6 carbon atoms, and R is any one of groups represented by
- or
- a structure represented by formula (4)
- wherein X3 is CH3, CH2F, CF3, F, Br or I, X6 is a leaving group selected from Cl, Br, I and —OSO2CF3, and R is defined equally as in the formula (3).
3 more elements
Dependencies are inferred from the claim text.