Mecs dialyzer method

A method for dialysis of blood, comprising:

• providing a dialyzer comprising:
• a plurality of semipermeable membrane sheets;
• and
• a plurality of flow separators, the membrane sheets and flow separators arranged in alternating configuration and coupled into a laminae stack defining a plurality of parallel microchannels layers, each microchannel layer comprising a plurality of first microchannels and a plurality of second microchannels, the first and second microchannels of each microchannel layer in fluid communication with each other via one of the plurality of membrane sheets therebetween, the blood-handling apparatus in fluid communication with the first microchannels, the dialysate-handling apparatus in fluid communication with the second microchannels;
• supplying the first microchannels with blood at a first end;
• supplying the second microchannels with dialysate at a second end;
• withdrawing blood from the first microchannels at a second end;
• and
• withdrawing dialysate from the second microchannels at a first end.