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AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsNicholas Alexander Melosh, Piyush Verma, Benjamin David Almquist
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Nanoscale probes for forming stable, non-destructive seals with cell membranes. The probes, systems including these probes, and methods of fabricating and using the probes described herein may be used to sense from, stimulate, modify, or otherwise effect individual cells or groups of cells. In particular, described herein are nanoscale cellular probes that may be used to span the lipid membrane of a cell to provide stable and long lasting access to the internal cellular structures. Thus, the probes described herein may be used as part of a system, method or device that would benefit from stable, non-destructive access across a cell membrane. In some variations the nanoscale probe devices or systems described herein may be used as part of a drug screening procedure.
A probe electrode for sealing with a cell membrane, the probe electrode comprising:
A probe electrode for inserting though a cell membrane, the probe electrode comprising:
A probe electrode for inserting through a cell membrane, the probe electrode comprising:
A method of electrically recording from a cell, the method comprising:
A method of establishing stable intracellular transmembrane access with a cell, the method comprising:
Dependencies are inferred from the claim text.