Method of detecting and treating tuberous sclerosis complex associated disorders

A method of diagnosing or determining the susceptibility to a tuberous sclerosis complex associated disorder in a subject, the method comprising:

• (a) providing from the subject a test cell population comprising cells capable of expressing one or more nucleic acid sequences selected from the group consisting of TSC 1-8, 10-12, 15-141 and 142;
• (b) measuring expression of one or more of the nucleic acid sequences in the test cell population;
• and
• (c) comparing the expression of the nucleic acid sequences in the test cell population to the expression of the nucleic acid sequences in a reference profile comprising at least one cell from a subject not suffering from a tuberous sclerosis complex associated disorder;
• and
• (d) identifying a difference in expression levels of the nucleic acid
• sequences, if present, in the test cell population and reference profile, thereby diagnosing or determining the susceptibility to a tuberous sclerosis complex associated disorder in the subject.