Methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid

A compound of Formula I:

• wherein,
• R1 is selected from OR3, —NHC(O)R5, —NHC(NH)NHR5, —NH(C5-C10heteroaryl) or a nitrogen atom part of a mono or bicyclic heteroaryl having from 5 to 10 ring members;
• R2 is selected from OR4, —NHC(O)R5, —NHC(NH)NHR5, —NH(C5-C10heteroaryl) or a nitrogen atom part of a mono or bicyclic heteroaryl having from 5 to 10 ring members, or R1 is a covalent bond and R2 is selected from O, NH, NC(O)R5, NC(NH)NHR5, and N(C5-C10heteroaryl) when R1 and R2 are taken together with their adjacent atoms to form a heterocycle;
• R3 is selected from hydrogen and a substituted or unsubstituted group selected from C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, C3-C15cycloalkyl, C3-C15heterocycloalkyl, C6-C15aryl, and C5-C15heteroaryl;
• R4 is a substituted or unsubstituted group selected from C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, C3-C15cycloalkyl, C3-C15heterocycloalkyl, C6-C15aryl, and C5-C15heteroaryl;
• and
• R5 is selected from hydrogen and a substituted or unsubstituted group selected from C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, C3-C15cycloalkyl, C3-C15heterocycloalkyl, C6-C15aryl, and C5-C15heteroaryl;
• or a pharmaceutically acceptable salt or solvate thereof.