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US 2012/0195846 A1Published application
Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom
AssigneeNektar Therapeutics AL, Corporation
InventorsJ. Milton Harris, Xuan Zhao
Life of this patent
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Abstract
A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.
Claims1
A hydrogel comprising,
- a co-polymerization product of a PEG multiacrylate and a heterobifunctional PEG conjugate wherein,
- (i) the multiacrylate has the formula of CH2═CHCO2-PEG-O2CCH═CH2, wherein PEG is polyethylene glycol, and
- (ii) the conjugate has the formula of (CH2═CZ—CO2-PEG-W-L)x-T, wherein Z is an alkyl group or hydrogen atom, W is a hydrolytically unstable linkage comprising a hydrolysable covalent bond, PEG is a polyethylene glycol, T is a protein, and x is number from 1 to 10.
Dependencies are inferred from the claim text.