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US 2012/0178923 A1Published application
Method and device for monitoring crystallization
AssigneeUniversite Joseph Fourier
InventorsNawale Khalef, Aziz Bakri
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AssigneeUniversite Joseph Fourier
InventorsNawale Khalef, Aziz Bakri
Estimating the term…
The use of a vapour source (10) in an isothermal system (8) to control the crystallization or recrystallization of a sample of solid material (9) which is initially at least partially amorphous and/or at least partially crystalline and contained within the system (8), the vapour source (10) including at least one solvent for crystallizing the solid material, the vapour diffusion (14) of which leads to the crystallization or recrystallization of the sample (9), the vapour source (10) being such that the quantities of heat exchanged within the system during the crystallization or recrystallization of the sample (9) other than the heat of crystallization or recrystallization of the sample are less than approximately 10%, particularly 5%, and advantageously 1% of the heat of crystallization or recrystallization of the sample. The vapour source (10) is preferably a pure solvent or a solvent mixture in which no solute is dissolved.
An isothermal system (8) to control the crystallization or recrystallization of a sample of solid material (9), which is initially at least partially amorphous and/or at least partially crystalline, contained in the system (8) with a vapour pressure, said isothermal system (8) comprising a vapour source for controlling the vapour pressure, said vapour source (10) comprising at least one solvent for crystallizing said solid material, the vapour diffusion (14) of which leads to the crystallization or recrystallization of the sample (9), said vapour source (10) being such that the quantities of heat exchanged within the system during the crystallization or recrystallization of the sample (9) other than the heat of crystallization or recrystallization of the sample are less than approximately 10%, in particular 5%, advantageously 1% of the heat of crystallization or recrystallization of the sample.
A method for controlling crystallization or recrystallization comprising:
The method according to 34, comprising before the measurement a stabilization of the temperature of the system until the system (8) reaches an equilibrium temperature, the system remaining at this equilibrium temperature during the measurement, the limitation of the diffusion rate being arranged so that the crystallization or recrystallization commences only when the system has reached the equilibrium temperature.
Dependencies are inferred from the claim text.