Compositions and methods for cardiac therapy
AssigneesThe Regents of the University of California, Ventrix, Inc.
InventorsKaren Christman, Jennifer Singelyn, Jessica Dequach, Adam Kinsey
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Abstract
Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.
Claims46
A composition comprising a material with a pore size of about 30 to 40 microns, wherein the material is injectable through a catheter with an inner diameter of 25 G or smaller.
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A composition comprising:
- decellularized extracellular matrix derived from cardiac tissue, wherein the matrix comprises material of a molecular weight of less than 300 kDa.
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A tissue culture device comprising:
- a composition comprising decellularized extracellular matrix derived from cardiac tissue;
- and a substrate.
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A method of manufacturing a composition comprising:
- a. decellularizing cardiac tissue;
- b. lyophilizing the decelled cardiac tissue;
- c. digesting the lyophilized tissue;
- d. lyophilizing the digested tissue;
- e. storing the digested tissue for up to 6 months at a temperature of less than 25° C.;
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- f. manufacturing a composition by incorporating the lyophilized digested tissue with a liquid.
A method for repairing cardiac tissue comprising injecting or implanting in a subject a composition comprising decellularized extracellular matrix derived from cardiac tissue.
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Dependencies are inferred from the claim text.