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AssigneesErasmus University Medical Center Rotterdam, Abbott Biologicals B.V.
InventorsEmmie DE WIT, Monique I.J. Spronken, Ron A.M. Fouchier, Albert D.M.E. Osterhaus
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The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens' eggs for over 50 years, but recently there have been considerable efforts to develop cell culture systems for vaccine production. In one embodiment, the invention provides a nucleic acid comprising an influenza gene segment and a bacteriophage polymerase promoter or a complementary strand of said nucleic acid, and a cell comprising such a nucleic acid capable of producing desired influenza virus. In another embodiment, the invention provides a composition comprising a cell or material derived from a cell according to the invention and a virus or material derived from a viral particle according to the invention.
1-20. (canceled)
A method for producing a pharmaceutical composition for generating immunological protection against infection of a subject with an influenza virus comprising preparing a composition comprising:
A method for producing a pharmaceutical composition for generating immunological protection against infection of a subject with an influenza virus comprising preparing a composition comprising:
A method for generating immunological protection against infection of a subject with an influenza virus comprising administering to a subject in need thereof a pharmaceutical composition comprising virus particles or viral proteins derived from the virus particles prepared by:
A replicative influenza virus particle produced, without the use of helper virus, by the method comprising:
A cell transfected with at least one nucleic acid, wherein said nucleic acid is chosen from:
A composition comprising virus particles or viral protein derived from the virus particles prepared without the use of helper virus, by the method comprising:
A nucleic acid comprising:
Dependencies are inferred from the claim text.