Compounds

A compound according to formula (I):

• wherein:
• X is O and Y is S or X is S and Y is O;
• —Z— is absent or is selected from the group consisting of —C(O)—, —C(S)—, —SO2— and —S(O);
• Ar is an arylene diradical;
• each of —R1′—R2 and —R3 is independently selected from the group consisting of —H, -Qalkyl, and -Qaryl, wherein Q is O, NH, S, or is absent;
• and
• Ar′— is a moiety of formula (II)
• wherein:
• each T1 is independently a nitrogen atom or a carbon atom substituted with R6, where each R6 is independently selected from the group consisting of hydrogen, C1-6 alkyl, halo, C1-6 alkoxy, alkylthio, alkylamino and dialkylamino;
• each T2 is independently a nitrogen atom or a carbon atom substituted with R7, where each R7 is independently selected from the group consisting of hydrogen, halo, nitro, cyano, carboxy, formyl or C(═O)OR4, C(═S)OR4, C(═O)SR4, C(═S)SR4, C(═O)NH2 and C(═S)NH2 wherein one or both hydrogen atoms may be independently exchanged for R4, C(O)R4, S(O)R4, S(O)2R4 and SO2OR4;
• and
• T3 is a nitrogen atom or a carbon atom substituted with R8, where R8 is selected from the group consisting of alkyl, alkoxy, alkylthio, OH, SH, halo, NHC(═O)R4, NHC(═S)R4 or NH2 wherein one or both hydrogen atoms may be independently exchanged for R4, OC(═O)R4, OC(═S)R4, SC(═O)R4, or SC(═S)R4,
• each R4 is independently selected from the group consisting of alkyl and aryl,
• with the proviso that where R8 is tert-butyl, at least one R7 is not hydrogen,
• or a physiologically acceptable salt, solvate, ester or amide thereof.