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US 2012/0142925 A1Published application
Process for the demethylation of oxycodone and related compounds
AssigneeAlpharma Aps
InventorsOle Heine Kvernenes, Anne Mette Nygard, Audun Hegges, Harald Haivorsen
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Abstract
A process is provided for the N-demethylation of certain morphinans by reaction with α-chloroethyl chloroformate followed by hydrolysis of the resulting intermediate.
Claims15
A process for the preparation of a compound of the formula (I) or a pharmaceutically acceptable salt thereof
- wherein X is CH2 or O or X is a protected keto group and R is H, CH3, O.CO.CH3 or a silyl protecting group, or a salt thereof, which process comprises the reaction of a compound of the formula
- with an α-chloroethyl chloroformate and hydrolysing the resulting intermediate, and optionally forming a pharmaceutical acceptable salt or free base thereof.
Dependencies are inferred from the claim text.