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US 2012/0142722 A1Published application
Conjugates of cytotoxic drugs
OwnerIlan Ziv, Anat Shirvan +1inventors
InventorsIlan Ziv, Anat Shirvan, Hagit Grimberg
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Abstract
Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders. In another aspect of the invention there is provided a conjugate, comprising a cytotoxic agent and a modulating moiety, the modulating moiety serving to target apoptotic cells.
Claims16
A compound represented by the structure as set forth in Formula III
- wherein R1, R2, R3 are each independently selected from hydrogen, C1, C2, C3, C4, C5, C6, C7, C8 linear or branched alkyl, or aryl or heteroaryl of one or two rings;
- M is either absent, or C1, C2, C3, or C4 alkylene;
- D is a cytotoxic agent;
- and
- L is either absent, or is a linker comprising C1, C2, C3, C4, C5, C6, C7, C8 linear or branched, substituted or unsubstituted alkylene, aryl or heteroaryl, of one or two rings, carbamate, amide or ester groups, or combinations thereof;
- and salts, hydrates and solvates of said compound.
3 more elements
A compound comprising the structure as set forth in Formula II
- wherein R1, R2, R3 are each independently selected from hydrogen, C1, C2, C3, C4, C5, C6, C7, C8 linear or branched alkyl, aryl or heteroaryl, of one or two rings, or combinations thereof;
- M is either absent or a C1, C2, C3, or C4 alkylene;
- and
- * indicates a linkage point to a cytotoxic agent, either directly or through a linker.
1 more element
(canceled)
Dependencies are inferred from the claim text.