US 2012/0129833 A1Published application

Cyclic ketoenols for therapy

AssigneeBayer Pharma Aktiengesellschaft

InventorsNingshu LIU, Kai Thede, Philip Lienau, Arne Scholz, Maher Najjar, Ulf Bomer, Knut Eis, Reiner Fischer

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Abstract

The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of diabetes, obesity, hyperlipidaemia, fatty livers and of disorders of the cardiovascular system.

Claims2

Dependent claims

(5s,8s)-3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,

(5s,8s)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-1-oxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-12-hydroxy-1-oxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
4-hydroxy-3-(3′,4′,5′-trifluoro-4-methylbiphenyl-3-yl)-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-3′,4′,5′-trifluorobiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-3′-fluoro-4′-methylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-4′-fluorobiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(4′-fluoro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(3′-chloro-4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one
(5s,8s)-3-(4-chloro-4′-fluorobiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-5-(methoxymethyl)-5-methyl-1,5-dihydro-2H-pyrrol-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-5-(2-methoxyethyl)-5-methyl-1,5-dihydro-2H-pyrrol-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-azaspiro[4.4]non-3-en-2-one,
rel-(5R,7R)-3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(2-methylpropoxy)-1-azaspiro[4.4]non-3-en-2-one,
rel-(5R,7S)-3-(4′-chloro-4-methylbiphenyl-3-yl)-7-(2-ethoxyethoxy)-4-hydroxy-1-azaspiro[4.4]non-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2-methoxyethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-2,3-dimethyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-11,11-dimethyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-1′-methyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-11,11-dimethyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-1′-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-1′-methyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-1′-en-10-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-2,3-dimethyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-7-ethoxy-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
rel-(5R,7R)-3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-8-ethoxy-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-8-methyl-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-8-ethyl-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-8-ethyl-3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4,6-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-1,4,9-trioxadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(3′-chloro-4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(4-chloro-3′,4′,5′-trifluorobiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(4-chloro-3′,4′-difluorobiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one,
(5s,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-chloro-4,6-dimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-oxaspiro[4.5]dec-3-en-2-one,
2-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazin-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(3′,4-dichloro-4′-fluorobiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
8-(2′,4′-difluoro-4-methylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-chloro-2,4-dimethylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(2′,4,4′-trichlorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(3′,4,4′-trichlorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4-chloro-2′,4′-difluorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)-6-fluoro-6-methyldihydro-1H,5H-pyrazolo[1,2-a]pyrazole-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)-6-fluoro-6-methyldihydro-1H,5H-pyrazolo[1,2-a]pyrazole-1,3(2H)-dione
4-(4′-chloro-4-methylbiphenyl-3-yl)-1,2-dimethyl-1H-pyrazole-3,5(2H,4H)-dione
4-(4,4′-dichlorobiphenyl-3-yl)-1,2-dimethyl-1H-pyrazole-3,5(2H,4H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-1H-5,8-methanopyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)tetrahydro-1H-5,8-methanopyrazolo[1,2-a]pyridazine-1,3(2H)-dione
for preparing a medicament for the prophylaxis and therapy of diabetes, obesity, hyperlipidaemia, fatty livers and of disorders of the cardiovascular system.

86 more elements

A method for prophylaxis and therapy of diabetes, obesity, hyperlipidaemia, fatty livers and of disorders of the cardiovascular system which comprises administering one or more of the following compounds:

(5s,8s)-3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-1-oxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-12-hydroxy-1-oxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
4-hydroxy-3-(3′,4′,5′-trifluoro-4-methylbiphenyl-3-yl)-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-3′,4′,5′-trifluorobiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-3′-fluoro-4′-methylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-4′-fluorobiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(4′-fluoro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(3′-chloro-4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one
(5s,8s)-3-(4-chloro-4′-fluorobiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-5-(methoxymethyl)-5-methyl-1,5-dihydro-2H-pyrrol-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-5-(2-methoxyethyl)-5-methyl-1,5-dihydro-2H-pyrrol-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-azaspiro[4.4]non-3-en-2-one,
rel-(5R,7R)-3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(2-methylpropoxy)-1-azaspiro[4.4]non-3-en-2-one,
rel-(5R,7S)-3-(4′-chloro-4-methylbiphenyl-3-yl)-7-(2-ethoxyethoxy)-4-hydroxy-1-azaspiro[4.4]non-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2-methoxyethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-2,3-dimethyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-11,11-dimethyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-1′-methyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-11,11-dimethyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-1′-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-1′-methyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-1′-en-10-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-2,3-dimethyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-7-ethoxy-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
rel-(5R,7R)-3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-8-ethoxy-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-8-methyl-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-8-ethyl-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-8-ethyl-3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4,6-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-1,4,9-trioxadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(3′-chloro-4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(4-chloro-3′,4′,5′-trifluorobiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(4-chloro-3′,4′-difluorobiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one,
(5s,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-chloro-4,6-dimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-oxaspiro[4.5]dec-3-en-2-one,
2-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazin-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(3′,4-dichloro-4′-fluorobiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
8-(2′,4′-difluoro-4-methylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-chloro-2,4-dimethylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(2′,4,4′-trichlorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(3′,4,4′-trichlorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4-chloro-2′,4′-difluorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)-6-fluoro-6-methyldihydro-1H,5H-pyrazolo[1,2-a]pyrazole-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)-6-fluoro-6-methyldihydro-1H,5H-pyrazolo[1,2-a]pyrazole-1,3(2H)-dione
4-(4′-chloro-4-methylbiphenyl-3-yl)-1,2-dimethyl-1H-pyrazole-3,5(2H,4H)-dione
4-(4,4′-dichlorobiphenyl-3-yl)-1,2-dimethyl-1H-pyrazole-3,5(2H,4H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-1H-5,8-methanopyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)tetrahydro-1H-5,8-methanopyrazolo[1,2-a]pyridazine-1,3(2H)-dione

86 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/213,436Filed 19 Aug 2011
Priority: 20 Aug 2010
Published: 24 May 2012
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

C07D 207/38
Oxygen or sulfur atoms: 2-Pyrrolones
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
A61P 3/06
Drugs for disorders of the metabolism: antihyperlipidemics

Family

Application61/375,375Us provisional application · filed 20 Aug 2010
US 2012/0129833 A1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

(5s,8s)-3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,

(5s,8s)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-1-oxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-12-hydroxy-1-oxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
4-hydroxy-3-(3′,4′,5′-trifluoro-4-methylbiphenyl-3-yl)-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-3′,4′,5′-trifluorobiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-3′-fluoro-4′-methylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4-chloro-4′-fluorobiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(4′-fluoro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(3′-chloro-4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one
(5s,8s)-3-(4-chloro-4′-fluorobiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5s,8s)-3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-5-(methoxymethyl)-5-methyl-1,5-dihydro-2H-pyrrol-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-5-(2-methoxyethyl)-5-methyl-1,5-dihydro-2H-pyrrol-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-azaspiro[4.4]non-3-en-2-one,
rel-(5R,7R)-3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(2-methylpropoxy)-1-azaspiro[4.4]non-3-en-2-one,
rel-(5R,7S)-3-(4′-chloro-4-methylbiphenyl-3-yl)-7-(2-ethoxyethoxy)-4-hydroxy-1-azaspiro[4.4]non-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2-methoxyethyl)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-2,3-dimethyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-11,11-dimethyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-1′-methyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-11,11-dimethyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-2-methyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-1′-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-1′-methyl-9,13-dioxa-1-azadispiro[4.2.5.2]pentadec-3-en-2-one,
11-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-1′-en-10-one,
11-(4,4′-dichlorobiphenyl-3-yl)-12-hydroxy-2,3-dimethyl-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-7-ethoxy-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
rel-(5R,7R)-3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethoxy)-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-8-ethoxy-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-8-methyl-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-8-ethyl-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
(5r,8r)-8-ethyl-3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4,6-dimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-methoxy-1-oxaspiro[4.5]dec-3-en-2-one,
11-(4′-chloro-4-methylbiphenyl-3-yl)-12-hydroxy-1,4,9-trioxadispiro[4.2.4.2]tetradec-11-en-10-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-7-(2-methoxyethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(methoxymethyl)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one,
3-(3′,4′-difluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(3′-chloro-4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(4-chloro-3′,4′,5′-trifluorobiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.4]non-3-en-2-one,
3-(4-chloro-3′,4′-difluorobiphenyl-3-yl)-4-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one,
(5s,8r)-3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4,4′-dichlorobiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-chloro-4,6-dimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
(5r,8s)-3-(4′-chloro-2,4,6-trimethylbiphenyl-3-yl)-4-hydroxy-1,9-dioxadispiro[4.2.4.2]tetradec-3-en-2-one,
3-(4′-chloro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-oxaspiro[4.5]dec-3-en-2-one,
3-(4′-chloro-4-methylbiphenyl-3-yl)-4-hydroxy-8-(2,2,2-trifluoroethoxy)-1-oxaspiro[4.5]dec-3-en-2-one,
2-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazin-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(3′,4-dichloro-4′-fluorobiphenyl-3-yl)tetrahydro-1H-pyrazolo[1,2-a]pyridazine-1,3(2H)-dione
8-(2′,4′-difluoro-4-methylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4′-chloro-2,4-dimethylbiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(2′,4,4′-trichlorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(3′,4,4′-trichlorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
8-(4-chloro-2′,4′-difluorobiphenyl-3-yl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)-6-fluoro-6-methyldihydro-1H,5H-pyrazolo[1,2-a]pyrazole-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)-6-fluoro-6-methyldihydro-1H,5H-pyrazolo[1,2-a]pyrazole-1,3(2H)-dione
4-(4′-chloro-4-methylbiphenyl-3-yl)-1,2-dimethyl-1H-pyrazole-3,5(2H,4H)-dione
4-(4,4′-dichlorobiphenyl-3-yl)-1,2-dimethyl-1H-pyrazole-3,5(2H,4H)-dione
2-(4′-chloro-4-methylbiphenyl-3-yl)tetrahydro-1H-5,8-methanopyrazolo[1,2-a]pyridazine-1,3(2H)-dione
2-(4,4′-dichlorobiphenyl-3-yl)tetrahydro-1H-5,8-methanopyrazolo[1,2-a]pyridazine-1,3(2H)-dione
for preparing a medicament for the prophylaxis and therapy of diabetes, obesity, hyperlipidaemia, fatty livers and of disorders of the cardiovascular system.

86 more elements

Facts

Application

13/213,436Filed 19 Aug 2011

Priority

20 Aug 2010

Published

24 May 2012

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C07D 207/38
Oxygen or sulfur atoms: 2-Pyrrolones
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
A61P 3/06
Drugs for disorders of the metabolism: antihyperlipidemics