Alpha-conotoxin mii analogs

An isolated conopeptide selected from the group consisting of:

• (SEQ ID NO:
• 15)
• (a) Gly-Cys-Cys-Ser-Asn-Pro-Val-Cys-His-Leu-Ala-
• His-Ser-Asn-Ala-Cys;
• (b) a derivative of (a) having α6-containing nicotinic acetylcholine receptor binding activity, wherein the derivative is a peptide in which the Pro residue is substituted with hydroxy-Pro or O-glycosylated hydroxy-Pro;
• one or both of the Ser residues is or are substituted with O-glycosylated Ser, Thr, O-glycosylated Thr or a synthetic hydroxylated amino acid;
• one or both of the Asn residues is or are substituted with N-glycosylated Asn;
• the Cys residues are in D or L configuration;
• one or more of the Cys residues is or are substituted with homocysteine in the D or L configuration;
• one or more pairs of Cys residues is or are replaced pairwise with a Ser/(Glu or Asp) combination or a Lys/(Glu or Asp) combination, wherein the synthetic hydroxylated amino acid is selected from the group consisting of 4-hydroxymethyl-Phe 4-hydroxyphenyl-Gly, 2,6-dimethyl-Tyr and 5-amino-Tyr;
• (c) a physiologically acceptable salt of (a) or (b).