Identification and monitoring of systemic lupus erythematosus
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsJoseph M. Ahearn, Susan M. Manzi, Jeannine Navratil
Life of this patent
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Abstract
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to reference levels of C4d on platelets of individuals without SLE and/or on platelets of the individual obtained at a different time. Kits for use in the above-described methods are provided along with computer readable media tangibly embodying executable instructions to perform the methods.
Claims20
A method for identifying systemic lupus erythematosus in an individual, the method comprising:
- quantitating complement C4d associated with platelets obtained from the individual;
- and
- comparing the quantity of complement C4d associated with platelets obtained from the individual with quantities of complement C4d associated with platelets obtained from individuals not having systemic lupus erythematosus;
- wherein greater quantities of C4d associated with platelets obtained from the individual as compared to quantities of C4d associated with platelets obtained from individuals not having systemic lupus erythematosus identifies systemic lupus erythematosus in the individual.
A method of monitoring disease activity of systemic lupus erythematosus in an individual comprising:
- quantitating complement C4d associated with platelets obtained from the individual;
- and
- comparing the quantity of complement C4d associated with platelets obtained from the individual with quantities of complement C4d associated with platelets obtained from either the individual at one or more different times or obtained from individuals not having systemic lupus erythematosus;
- wherein greater quantities of C4d associated with platelets obtained from the individual as compared to quantities of C4d associated with platelets obtained from either the individual at one or more different times or obtained from individuals not having systemic lupus erythematosus correlates with the presence of systemic lupus erythematosus in the individual.
A kit for use in identifying systemic lupus erythematosus in an individual, comprising
- a package containing a conjugate of an antibody specific for complement C4d and a first labeled moiety;
- and
- instructions for to use of the conjugate to identify complement C4d associated with platelets.
A computer readable medium tangibly embodying executable instructions to perform a method for identifying systemic lupus erythematosus in an individual, the method comprising:
- quantitating complement C4d associated with platelets obtained from the individual;
- and
- comparing the quantity of complement C4d associated with platelets obtained from the individual with quantities of complement C4d associated with platelets obtained from individuals not having systemic lupus erythematosus;
- wherein greater quantities of C4d associated with platelets obtained from the individual as compared to quantities of C4d associated with platelets obtained from individuals not having systemic lupus erythematosus correlates with the presence of systemic lupus erythematosus in the individual.
A computer readable medium tangibly embodying executable instructions to perform a method for monitoring disease activity of systemic lupus erythematosus in an individual, the method comprising:
- quantitating complement C4d associated with platelets obtained from the individual;
- and
- comparing the quantity of complement C4d associated with platelets obtained from the individual with quantities of complement C4d associated with platelets obtained from either the individual at one or more different times or individuals not having systemic lupus erythematosus;
- wherein greater quantities of C4d associated with platelets obtained from the individual as compared to quantities of C4d associated with platelets obtained from either the individual at one or more different times or individuals not having systemic lupus erythematosus correlates with the presence of systemic lupus erythematosus in the individual.
Dependencies are inferred from the claim text.