Test for Predicting Neutralization of Asparaginase Activity
AssigneeErytech Pharma
InventorYann Godfrin
Life of this patent
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Abstract
Method of in vitro measurement of the presence of factors that are able to neutralize asparaginase activity in a sample of blood, plasma, serum or derived medium that may contain asparaginase neutralizing factors, obtained from a patient, comprising mixing of said sample with asparaginase, incubation of said mixture, then measurement of the residual asparaginase activity in the mixture and determination or quantification of the presence of said neutralizing factors. Method for predicting the efficacy of a treatment with asparaginase.
Claims17
A method for predicting whether an asparaginase can be active in a patient, wherein one measures in vitro the presence of factors that neutralize asparaginase activity in a sample of blood, plasma, serum or derived medium that may contain said neutralizing factors, obtained from said patient.
Method of treatment of an asparaginase-sensitive pathology in a patient, which comprises:
- (A) application of the method of in vitro determination of a patient's capacity for responding to treatment with a given form of asparaginase (notably free or modified form), in which a sample of blood, plasma, serum or derived medium that may contain asparaginase neutralizing factors, obtained from said patient, is submitted to the method comprising mixing of said sample with said forms of asparaginase, incubation of said mixture, then measurement of the residual asparaginase activity in the mixture and of the patient's capacity to respond (i) positively to treatment with this form of asparaginase or (ii) not respond to it or (iii) only respond incompletely, and
- (B) treatment of the pathology by means of this asparaginase in case (i) or by means of another form of asparaginase in cases (ii) and (iii).
Dependencies are inferred from the claim text.