Nanostructure surface coated medical implants and methods of using the same
AssigneesThe Regents of the University of California, The Penn State Research Foundation
InventorsTejal A. Desai, Ketal C. Popat, Craig A. Grimes
Life of this patent
Estimating the term…
Abstract
Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.
Claims106
A medical implant, comprising:
- a surface or film comprising a plurality of nanofibers, nanotubes, or microwells, where said nanofibers, nanotubes, or microwells comprise a bioactive agent for elution to the surrounding tissue upon placement in a subject.
A method of treating a patient in need of a medical implant, comprising:
- placing a medical implant into the patient, wherein the medical implant comprises a surface or film comprising a plurality of nanofibers, nanotubes, or microwells, where said nanofibers, nanotubes, or microwells comprise a bioactive agent for elution to the surrounding tissue upon placement in a subject.
A medical implant, comprising:
- a surface or film comprising a plurality of nanofibers, nanotubes, or microwells, where said nanofibers, nanotubes, or microwells comprise a bioactive agent for elution to the surrounding tissue upon placement in a subject, and
- wherein said nanotopography is less than about 750 μm in thickness.
A medical implant, comprising:
- a surface or film comprising a plurality of nanofibers, nanotubes, or microwells, where said nanofibers, nanotubes, or microwells comprise a bioactive agent for elution to the surrounding tissue upon placement in a subject, and
- wherein said cell contacting surface or film expands or unfurls in the presence of a hydrating liquid.
Dependencies are inferred from the claim text.