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US 2012/0107827 A1Published application
PSMCs As Modifiers of the RB Pathway and Methods of Use
AssigneeExelixis, Inc.
InventorsALBERT K. TAI, CHUNYAN SONG, MICHAEL MARTIN OLLMANN, LUCILE A. GILLETT, JOANNE I. ADAMKEWICZ, KIM LICKTEIG
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Abstract
Human PSMC genes are identified as modulators of the RB pathway, and thus are therapeutic targets for disorders associated with defective RB function. Methods for identifying modulators of RB, comprising screening for agents that modulate the activity of PSMC are provided.
Claims12
-25. (canceled)
A method for diagnosing cancer in a subject comprising:
- (a) obtaining a biological sample from the subject;
- (b) determining the level of expression of PSMC in the biological sample of step (a);
- (c) comparing the level of expression of PSMC in the biological sample of step (b) with the level of expression of PSMC in a control sample;
- and
- (d) determining an elevated level of PSMC expression in the biological sample compared with the control sample, wherein said elevated level indicates a likelihood of cancer.
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Dependencies are inferred from the claim text.