Different serotypes of vesicular stomatitis virus as expression vectors for immunization regimens
OwnerChil-Yong Kang, Gyoung Nyoun Kiminventors
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Abstract
Immunization platforms, immunization regimes and medicaments useful for inducing an immune response in a mammal and preventing or treating a pathogenic infection in a mammal, wherein said immunization platforms and medicaments comprise a recombinant vesicular stomatitis virus (VSV) of one serotype and a rVSV of another serotype and are used in a prime-boost immunization regime. In aspects of the invention one VSV serotype is Indiana and the other VSV serotype is New Jersey.
Claims24
An immunization platform for use in a prime boost immunization strategy characterized in that said immunization platform comprises:
- a. one vaccine or immunogenic composition comprising a recombinant vesicular stomatitis virus (rVSV) of one serotype, and
- b. another vaccine or immunogenic composition comprising a rVSV of another serotype.
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A medicament useful for inducing an immune response against a pathogen, characterized in that said medicament comprises two vaccines or immunogenic compositions used in combination in a prime boost strategy:
- a. one vaccine or immunogenic composition comprising a recombinant vesicular stomatitis virus (rVSV) of one serotype expressing one or more proteins of the pathogen, and
- b. another vaccine or immunogenic composition comprising a rVSV of another serotype expressing the one or more proteins of the pathogen.
A method for preventing or treating an infection caused by a pathogen, characterized in that said method comprises:
- c. administering to a subject an effective amount of a first vaccine or immunogenic composition comprising a rVSV of a first serotype expressing one or more proteins of the pathogen, and
- d. administering to the subject an effective amount of a second vaccine or immunogenic composition comprising a rVSV of a second serotype expressing the one or more proteins of the pathogen.
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Dependencies are inferred from the claim text.