Compounds for treating proliferative disorders

A compound represented by formula (XX):

• or a tautomer, pharmaceutically acceptable salt thereof, wherein:
• Z7 are Z8 are independently O, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Y2 is N(R5)— or —C(═X5)—;
• Y3 is —C(O)— or —S(O)q—;
• X5 is C(R9)2 or N—X6;
• X6 is R17, —OR17, —N(R26)2, or —NHR27;
• R″1 and R″2 are independently an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, or an optionally substituted heteroaryl;
• R3 and R4 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
• R5 and R6 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
• each R9 is independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, halo, nitro, cyano, guanadino, —OR17, —NR40R41, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —OP(O)(OR17)2, —SP(O)(OR17)2, —SRN, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pNR19R20;
• R13 for each occurrence is, independently, —H, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —NR18C(O)R17, —OP(O)(OR17)2, —SP(O)(OR17)2, —SRN, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pNR19R20, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R17 and R18, for each occurrence, are, independently, —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R19 and R20, for each occurrence, are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• or R19 and R20, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
• R26 is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R27 is —H, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R40 and R41, for each occurrence, are independently H, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —NR18C(O)R17, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl, or R40 and R41, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
• m is 0 or 1;
• p is 1 or 2;
• and
• q is 1 or 2.

A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following formulas:

• or a tautomer, pharmaceutically acceptable salt, or prodrug thereof, wherein:
• Z1 are Z2 are independently O, S, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Z′1 and Z′2 are independently Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Z3 and Z4 are independently O, S, Se, Te, Po, N(R13)m, P(R13)m, As(R13)m, Sb(R13)m, or Bi(R13)m;
• provided that when one of Z1 or Z2 is S and the other is O or S, then Z3 and Z4 are not O or S, and provided that when Z1 and Z2 are both O, then Z3 and Z4 are not both S;
• Z′3 and Z′4 are independently N, P, As, Sb, or Bi;
• Z5 are Z6 are independently O, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Z7 are Z8 are independently O, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Y is —C(═X5)—, or —N(R5)—;
• Y2 is —N(R5)— or —C(═X5)—;
• Y3 is —C(O)— or —S(O)q—;
• X1 and X2 are each independently C(R3)p, O, S, Se, Te, Po, N(R13)m, P(R13)m, As(R13)m, Sb(R13)m or Bi(R13)m;
• X3 is C(R3)p, O, S, Se, Te, Po, N(R13)m, P(R13)m, As(R13)m, Sb(R13)m, or Bi(R13)m;
• X5 is C(R9)2 or N—X6;
• X6 is R17, —OR17, —N(R26)2, or —NHR27;
• R″1 and R″2 are independently an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, or an optionally substituted heteroaryl;
• R3 and R4 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
• R5 and R6 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
• R7 and R8 are each independently —H or an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, or R7 is —H and R8 is an optionally substituted aryl or an optionally substituted heteroaryl;
• each R9 is independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, halo, nitro, cyano, guanadino, —OR17, —NR40R41, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —OP(O)(OR17)2, —SP(O)(OR17)2, —SRN, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pNR19R20;
• R13 for each occurrence is, independently, —H, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —NR18C(O)R17, —OP(O)(OR17)2, —SP(O)(OR17)2, —SRN, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pNR19R20, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R17 and R18, for each occurrence, are, independently, —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R19 and R20, for each occurrence, are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• or R19 and R20, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
• R22 is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R26 is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R27 is —H, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R40 and R41, for each occurrence, are independently H, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —NR18C(O)R17, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl, or R40 and R41, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
• m is 0 or 1;
• p is 1 or 2;
• and
• q is 1 or 2.

A method of treating a subject with a cancer or preventing the reoccurrence of cancer in a subject, said method comprising administering to the subject an effective amount of a compound represented by the following formulas:

• or a tautomer, pharmaceutically acceptable salt, or prodrug thereof, wherein:
• Z1 are Z2 are independently O, S, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Z′1 and Z′2 are independently Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Z3 and Z4 are independently O, S, Se, Te, Po, N(R13)m, P(R13)m, As(R13)m, Sb(R13)m, or Bi(R13)m;
• provided that when one of Z1 or Z2 is S and the other is O or S, then Z3 and Z4 are not O or S, and provided that when Z1 and Z2 are both O, then Z3 and Z4 are not both S;
• Z′3 and Z′4 are independently N, P, As, Sb, or Bi;
• Z5 are Z6 are independently O, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Z7 are Z8 are independently O, Se, Te, Po, NR13, PR13, AsR13, SbR13 or BiR13;
• Y is —C(═X5)—, or —N(R5)—;
• Y2 is —N(R5)— or —C(═X5)—;
• Y3 is —C(O)— or —S(O)q—;
• X1 and X2 are each independently C(R3)p, O, S, Se, Te, Po, N(R13)m, P(R13)m, As(R13)m, Sb(R13)m or Bi(R13)m;
• X3 is C(R3)p, O, S, Se, Te, Po, N(R13)m, P(R13)m, As(R13)m, Sb(R13)m, or Bi(R13)m;
• X5 is C(R9)2 or N—X6;
• X6 is R17, —OR17, —N(R26)2, or —NHR27;
• R″1 and R″2 are independently an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, or an optionally substituted heteroaryl;
• R3 and R4 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
• R5 and R6 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
• R7 and R8 are each independently —H or an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, or R7 is —H and R8 is an optionally substituted aryl or an optionally substituted heteroaryl;
• each R9 is independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, halo, nitro, cyano, guanadino, —OR17, —NR40R41, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —OP(O)(OR17)2, —SP(O)(OR17)2, —SRN, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pNR19R20;
• R13 for each occurrence is, independently, —H, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —NR18C(O)R17, —OP(O)(OR17)2, —SP(O)(OR17)2, —SRN, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pNR19R20, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R17 and R18, for each occurrence, are, independently, —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R19 and R20, for each occurrence, are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• or R19 and R20, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
• R22 is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R26 is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R27 is —H, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• R40 and R41, for each occurrence, are independently H, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)NR19R20, —NR18C(O)R17, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl, or R40 and R41, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
• m is 0 or 1;
• p is 1 or 2;
• and
• q is 1 or 2.