# US 2012/0083592 A1 · Continuous preparation method of ginseng ginsenosides and polysaccharides

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- Number: US 2012/0083592 A1
- Document ID: US20120083592A1
- Status: Published application
- Kind: A1
- Application number: 12/894,387
- Filed: 2010-09-30
- Published: 2012-04-05
- Earliest claimed: 2010-09-30
- Inventors: Zer-Ran Yu; Be-Jen Wang
- Web page: https://patentgrep.com/patent/US20120083592A1

## CPC

- C08B 37/0003: {General processes for their isolation or fractionation, e.g. purification or extraction from biomass}
- B01J 3/008: {Processes carried out under supercritical conditions}
- C07J 17/00: Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton (cardanolide, bufanolide C07J19/00)
- C08B 37/006: {Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof}
- B01J 2219/00135: Electric resistance heaters
- Y02P 20/54: using solvents, e.g. supercritical solvents or ionic liquids
- C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21)
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- C07J: STEROIDS (seco-steroids C07C)
- Y02P: CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

## Abstract

The present invention provides a continuous preparation method of ginseng ginsenosides and polysaccharides, whereby the ginseng extract liquor and supercritical solvent are poured continuously into a separation tank at 10-30 MPa and 40-60° C. as well as a preset flow rate; so the ginseng extract liquor can be separated in the separation tank to obtain ginsenosides and polysaccharides at different positions of the separation tank.

## Claims

### Claim 1

A continuous preparation method of ginseng ginsenosides and polysaccharides, ginseng extract liquor and supercritical solvent are poured at a preset flow rate into a separation tank, under operating conditions such as: 10-30 MPa and 40-60° C.; so, the ginseng extract liquor can be separated in the separation tank to obtain ginseng ginsenosides and polysaccharides at different positions of the separation tank.

### Claim 2 (depends on 1)

The composition method defined in claim 1, wherein the ginseng extract liquor is poured at 1-3 L/hr into the separation tank, and the supercritical solvent is poured at 3-9 L/hr into the separation tank.

### Claim 3 (depends on 1)

The composition method defined in claim 1, wherein the supercritical solvent is a CO2 fluid in supercritical state.

### Claim 4 (depends on 1)

The composition method defined in claim 1, wherein the ginseng ginsenosides is separated at top of the separation tank, and the polysaccharides is separated at bottom of the separation tank.

### Claim 5 (depends on 1)

The composition method defined in claim 1, wherein the optimum operating condition of the separation tank is: 30 MPa and 55-60° C.

### Claim 6 (depends on 1)

The composition method defined in claim 1, wherein the continuous separation system comprises:
a separation tank, wherein an electric heater is placed;
a holding tank, connected with the separation tank to accommodate ginseng extract liquor;
a supercritical fluid vessel, connected with the separation tank to provide supercritical fluid;
a high-pressure metering pump, connected between the supercritical fluid vessel and separation tank;
a reactant metering pump, connected between the holding tank and separation tank;
a precooler, connected between the supercritical fluid vessel and high-pressure metering pump;
two preheaters, connected separately between the high-pressure metering pump, reactant metering pump and separation tank;
a temperature controller, connected with the electric heater; and
several valves, arranged between two preheaters and the separation tank.

### Claim 7 (depends on 6)

The system defined in claim 6, wherein said separation tank is composed of a tank body and a monomer body in the tank body; the electric heater is set in the tank body.

### Claim 8 (depends on 7)

The system defined in claim 7, wherein said separation tank is made of stainless steel.

### Claim 9 (depends on 6)

The system defined in claim 6, wherein the supercritical fluid vessel is used to accommodate supercritical CO2 fluid.