# US 2012/0083573 A1 · Novel pdms-pvp block copolymers

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- Number: US 2012/0083573 A1
- Document ID: US20120083573A1
- Status: Published application
- Kind: A1
- Application number: 13/325,584
- Filed: 2011-12-14
- Published: 2012-04-05
- Earliest claimed: 2007-03-15
- Assignees: Dsm IP Assets B.V.
- Inventors: James PARAKKA; Keith R. McCrea; Robert S. Ward
- Web page: https://patentgrep.com/patent/US20120083573A1

## CPC

- C08F 293/00: Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule (on to polymers modified by introduction of unsaturated end groups C08F290/02)
- A61L 15/26: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)}
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C08F 8/10: Acylation
- C08F 8/14: Esterification
- C08G 77/442: containing vinyl polymer sequences
- C08G 77/452: containing nitrogen-containing sequences
- C08L 53/00: Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L 83/10: Block- or graft-copolymers containing polysiloxane sequences (obtained by polymerising a compound having a carbon-to-carbon double bond on to a polysiloxane C08L51/08, C08L53/00)
- G02B 1/043: {Contact lenses}
- C08F 2810/40: taking place solely at one end or both ends of the polymer backbone, i.e. not in the side or lateral chains
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)
- G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS

## Abstract

Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.

## Claims

### Claim 1

An amphipathic diblock copolymer compound bearing polymerizable functionality having the following general structure:

### Claim 2 (depends on 1)

The compound of claim 1, wherein R1=butyl; “a” is from 2 to 50; R2═(CH2)3; “b”=1; X═O; R3═H; R4=pyrrolidinone; “d”=1-10,000; R5═C(CH3)2—O—CH2—CH2; Y═O; and R6═CH3.

### Claim 3 (depends on 1)

The compound of claim 1, wherein R1=butyl; “a” is from 2 to 50; R2═(CH2)3; “b”=1; X═O; R3═H; R4=pyrrolidinone; “d”=1-10,000; R5═C(CH3)2—O—CH2—CH2; Y═NH; and R6═CH3.

### Claim 4 (depends on 1)

The compound of claim 1, wherein R1=butyl; “a” is from 2 to 50; R2═(CH2)3; “b”=1; X═NH; R3═H; R4=pyrrolidinone; “d”=1-10,000; R5═C(CH3); Y═O; and R6═CH3.

### Claim 5 (depends on 1)

The compound of claim 1, wherein R1=butyl; “a” is from 2 to 50; R2═(CH2)3—O—(CH2)2; “b”=1; X═O; R3═H; R4=pyrrolidinone; “d”=1-10,000; R5═C(CH3); Y═NH; and R6═CH3.

### Claim 6 (depends on 1)

The amphipathic diblock copolymer of claim 1, formulated for use in the preparation of silicone hydrogel lenses.

### Claim 7 (depends on 1)

The amphipathic diblock copolymer of claim 1, formulated for use in the preparation of an oxygen permeable and wettable backing material for a wound healing device.

### Claim 8 (depends on 1)

The amphipathic diblock copolymer of claim 1, formulated for use in the preparation of a scaffold for tissue engineering.

### Claim 9 (depends on 1)

The amphipathic diblock copolymer of claim 1, formulated for use in the preparation of a component for controlled drug release.