# US 2012/0073577 A1 · Combination pressure therapy for treatment of ischemia and heart conditions, diabetes, alzheimer's disease and cancer

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- Number: US 2012/0073577 A1
- Document ID: US20120073577A1
- Status: Published application
- Kind: A1
- Application number: 13/011,058
- Filed: 2011-01-21
- Published: 2012-03-29
- Earliest claimed: 2006-02-08
- Assignees: Cvac Systems, Inc.
- Inventors: Carl Linton; Allen Ruszkowski; Thomas Jackson Tidwell
- Web page: https://patentgrep.com/patent/US20120073577A1

## CPC

- A61B 5/14535: {for measuring haematocrit}
- A61B 5/411: {Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance}
- A61G 10/023: {Rooms for the treatment of patients at over- or under-pressure or at a variable pressure}
- A61G 10/026: {for hyperbaric oxygen therapy}
- A61K 38/1816: {Erythropoietin [EPO]}
- A61K 38/193: {Colony stimulating factors [CSF]}
- A61B 5/021: Measuring pressure in heart or blood vessels
- A61B 5/145: Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value {; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue} (non-radiation detecting or locating of foreign bodies in blood A61B5/06)
- A61B 5/4514: {Cartilage}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61G: TRANSPORT, PERSONAL CONVEYANCES OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS (appliances for aiding patients or disabled persons to walk A61H3/00); OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES (embalming corpses A01N1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Methods for administering pressure changes to a user for the treatment and prevention of diseases and conditions are disclosed herein. Methods of administering Cyclic Variations in Altitude Conditioning Sessions (CVAC Session(s)) for the treatment of ischemia, diabetes and associated complications, Alzheimer's disease, and cancer are disclosed herein.

## Claims

### Claim 1

A method, comprising:
administering at least two CVAC (Cyclic Variations in Altitude Condition) sessions to a mammal in a pressure vessel unit, the at least two CVAC sessions each having a duration of 20 minutes, and including a start point of ambient pressure at the delivery site, an end point of ambient pressure at the delivery site, and a plurality of atmospheric pressure targets executed between the start point and said end point; and
measuring at least one physiological marker associated with the mammal prior to the administering.

### Claim 2 (depends on 1)

The method of claim 1, wherein the administering is configured to treat at least one complication associated with diabetes in the mammal, the at least one complication including at least one of diabetic ulcerations, vascular disease, heart disease, visual disorders, or kidney disease.

### Claim 3 (depends on 1)

The method of claim 1, further comprising:
measuring the at least one physiological marker associated with the mammal after the administering.

### Claim 4 (depends on 3)

The method of claim 3, further comprising:
measuring an efficacy of the at least two CVAC sessions based on a change to the at least one physiological marker associated with the mammal prior to and after the administering.

### Claim 5 (depends on 1)

The method of claim 1, wherein the at least one physiological marker includes at least one of insulin, HbA1c, glucose tolerance, glucose transport, GLUT expression, HIF-1α expression, VEGF production, hematocrit, erythropoietin production, oxygenation of tissues in the mammal, or angiogenesis within tissues of the mammal.

### Claim 6 (depends on 1)

The method of claim 1, further comprising:
administering at least one pharmaceutical compound.

### Claim 7 (depends on 5)

The method of claim 5, wherein the pharmaceutical compound is insulin.

### Claim 8 (depends on 1)

The method of claim 1, wherein each of the plurality of pressure targets is equivalent to a pressure in a range of 2,000 ft and 22,500 ft above atmospheric pressure.

### Claim 9 (depends on 1)

The method of claim 1, wherein each of the plurality of pressure targets is equivalent to a pressure in a range of 1,000 ft and 11,000 ft above atmospheric pressure.