Systems for Treating Tissue Sites Using Electroporation
OwnerBoris Rubinsky, Gary Onik +1inventors
InventorsBoris Rubinsky, Gary Onik, Paul Mikus
Life of this patent
Estimating the term…
Abstract
A system for treating a tissue site. At least first and second mono-polar electrodes are configured to be introduced at or near a tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tissue site, to create necrosis of cells of the tissue site, but insufficient to create a thermal damaging effect to a majority of the tissue site.
Claims21
A system for electrically ablating a tissue site, comprising:
- at least two electrodes configured to be introduced at or near a tissue site of a patient;
- and
- a voltage pulse generator configured to generate and apply between the electrodes a plurality of electrical pulses with each pulse having:
- a sufficiently high predetermined amplitude to electrically ablate cells in the tissue site;
- and
- a leading edge that ramps to the predetermined amplitude at a selected rate that reduces arcing at the electrodes.
A system for treating a tissue site by irreversible electroporation, comprising:
- at least two electrodes configured to be introduced at or near a tissue site of a patient;
- and
- a voltage pulse generator configured to generate and apply between the electrodes a plurality of electrical pulses with each pulse having:
- a sufficiently high predetermined amplitude to induce irreversible electroporation of cells in the tissue site;
- and
- a leading edge that ramps to the predetermined amplitude at a selected rate that reduces arcing at the electrodes.
A method for electrically ablating a tissue site, comprising:
- introducing at least two electrodes at or near a tissue site of a patient;
- and
- applying between the electrodes a plurality of electrical pulses with each pulse having:
- a sufficiently high predetermined amplitude to electrically ablate cells in the tissue site;
- and
- a leading edge that ramps to the predetermined amplitude at a selected rate that reduces arcing at the electrodes.
Dependencies are inferred from the claim text.