Stabilized glucagon solutions and uses therefor
AssigneeLegacy Emanuel Hospital & Health Center
InventorsW. Kenneth Ward, Richard D. DiMarchi
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Abstract
Stabilized glucagon solutions, methods of storing and using the stabilized glucagon solutions, and drug delivery devices containing the stabilized glucagon solutions. In some embodiments, the glucagon solutions may be alkaline, such as with a pH of at least about 9. The glucagon solutions may be resistant to aggregation of glucagon when the solutions are stored for a prolonged period, such as at least about three days, at room temperature and/or physiological temperature.
Claims20
A composition for treating a glucagon-responsive medical condition, comprising:
- a pharmaceutically-acceptable aqueous solution of glucagon,
- wherein the solution has a pH of greater than about 9, and
- wherein the glucagon remains substantially non-aggregated when the solution is stored at a physiological temperature for at least three days.
A method of treating a glucagon-responsive medical condition, comprising:
- providing an aqueous solution of glucagon at a pH of greater than about 9;
- storing the solution in liquid form for at least three days at a physiological temperature without substantial aggregation of the glucagon;
- and
- delivering at least a portion of the solution into a subject after the step of storing.
A drug delivery system, comprising:
- a container holding an aqueous solution of glucagon at a pH of greater than about 9, the glucagon remaining substantially non-aggregated when the solution is stored at a physiological temperature for at least three days;
- and
- an outlet through which the solution is configured to be driven from the container for delivery into a subject.
Dependencies are inferred from the claim text.