Photodynamic therapy including light pretreatment
AssigneeCase Western Reserve University
InventorsKevin D. Cooper, Elma D. Baron
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Abstract
A method of photodynamic therapy is described that includes administering a therapeutically effective amount of a photosensitizer to an area of tissue such as the skin of a subject, delivering a first photoirradiation with light having a wavelength suitable to activate the photosensitizer to the area of skin, allowing a sufficient interval of time to pass for an effective amount of the photosensitizer to penetrate the tissue, and then delivering a second photoirradiation with light having a wavelength suitable to activate the photosensitizer to provide a therapeutic effect. Use of multiple photoirradiations increases the speed with which the photosensitizer can penetrate the tissue to reach the area where the source of the disease is present.
Claims17
A method of photodynamic therapy comprising administering a therapeutically effective amount of a photosensitizer to an area of tissue of a subject, delivering a first photoirradiation with light having a wavelength suitable to activate the photosensitizer to the area of tissue, allowing a sufficient interval of time to pass for an effective amount of the photosensitizer to substantially penetrate the tissue, and then delivering a second photoirradiation with light having a wavelength suitable to activate the photosensitizer to provide a therapeutic effect.
Dependencies are inferred from the claim text.