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US 2012/0071704 A1Published application
Mitochondrial localization of muc1
OwnerDonald W. KUFEinventor
Life of this patent
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Abstract
The invention provides methods of identifying and making compounds that inhibit the interaction between MUC1 and either or both of HSP70 and HSP90. Also embraced by the invention are in vivo and in vitro methods of inhibiting such an interaction.
Claims18
1-13. (canceled)
An in vivo method of inhibiting binding of MUC1 to HSP70 or HSP90 in a cancer cell that expresses MUC1, the method comprising:
- (a) identifying a subject as having a cancer that expresses MUC1 or is suspected to express MUC1;
- and
- (b) administering to the subject a compound or, where the compound is a polypeptide, a nucleic acid comprising a nucleic acid sequence encoding the polypeptide, the nucleic acid sequence being operably linked to a transcriptional regulatory element (TRE), wherein the compound inhibits binding of HSP70 or HSP90 to the cytoplasmic domain of MUC1.
Dependencies are inferred from the claim text.