Novel forms of cddo methyl ester
AssigneeReata Pharmaceuticals, Inc.
InventorsJohn Walling, Stephan D. Parent, David T. Jonaitis, Robert M. Kral, JR.
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Abstract
A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.
Claims1
A glassy solid form of CDDO-methyl ester, having an x-ray powder diffraction pattern with a halo peak at approximately 13.5°2θ, as shown in FIG. 2C, and a Tg.
Dependencies are inferred from the claim text.