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US 2012/0071665 A1Published application
Method for producing olmesartan medoxomil
AssigneeDaiichi Sankyo Company, Limited
InventorShigeo Yanagihara
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Abstract
A method for producing high-purity olmesartan medoxomil is provided in which a solvent containing water is used in steps of tritylation and DMDO esterification of olmesartan.
Claims23
A method for producing olmesartan medoxomil comprising a step in which trityl olmesartan medoxomil is produced by
- (i) reacting olmesartan with trityl halide and then
- (ii) reacting it with DMDO halide,
- in a solvent in the presence of a base, wherein water is present in the reaction mixture in the tritylation step (i) and the DMDO esterification step (ii).
Olmesartan medoxomil comprising 0.3% or less of olmesartan medoxomil dehydrate.
Dependencies are inferred from the claim text.