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US 2012/0071655 A1Published application
Process for enantiomeric separation of racemic dihydro-1,3,5, triazines via preferential crystallization
AssigneePoxel
InventorsMatthias Helmreich, Claus-Peter Niesert, Daniel Cravo, Gérard Coquerel, Gullaume Levilain, Saoussen Wacharine-Antar, Pascal Cardinael
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Abstract
A new process for the enantiomeric separation of racemic 3,6-dihydro-1,3,5-triazine derivatives for the treatment of disorders associated with insulin-resistance syndrome, by preferential crystallization.
Claims11
A process for the resolution of the two optical enantiomers of a salt of compounds of the formula I
- in which
- R is methyl, phenyl, 4-hydroxy-phenyl or 4-methoxyphenyl,
- Z is hydrochloric acid, hydrobromic acid, nitric acid, acetic acid, propanoic acid, 2,4-dichlorophenylacetic acid, 3,4-dichlorophenyl acetic acid, barbituric acid, chloroacetic acid, adipic acid, glycolic acid, succinic acid, or (±)di-O,O′-p-tolyltartaric acid,
- or a tautomer thereof, by preferential crystallization.
1 more element
Dependencies are inferred from the claim text.