Tetrahydropyran nucleic acid analogs
AssigneeIsis Pharmaceuticals, Inc.
InventorsEric E. Swayze, Andrew M. Siwkowski, Balkrishen Bhat, Thazha P. Prakash, Charles Allerson, Punit P. Seth
Life of this patent
Estimating the term…
Abstract
The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
Claims23
An oligomeric compound comprising at least one tetrahydropyran nucleoside analog of the formula:
- wherein independently for each tetrahydropyran nucleoside analog of said formula:
- Bx is a heterocyclic base moiety;
- T3 and T4 are each, independently, an internucleoside linking group linking the tetrahydropyran nucleoside analog to the oligomeric compound or one of T3 and T4 is an internucleoside linking group linking the tetrahydropyran nucleoside analog to the oligomeric compound and the other of T3 and T4 is H, a hydroxyl protecting group, a linked conjugate group or a 5′ or 3′-terminal group;
- and
- wherein said oligomeric compound comprises from about 8 to about 40 monomer subunits.
Dependencies are inferred from the claim text.