Risperidone immunoassay
AssigneeSaladax Biomedical Inc.
InventorsSalvatore J. Salamone, Jodi Blake Courtney, Daniel J. Cline, Howard Sard, Vishnumurthy Hegde
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Abstract
Novel conjugates and immunogens derived from risperidone and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of risperidone and paliperidone in biological fluids.
Claims32
An antibody which is selectively reactive with a pharmaceutically active anti-psychotic drug selected from the group of consisting of risperidone, paliperidone and mixtures thereof wherein said antibody reacts with risperidone and paliperidone and has little substantial reactivity with the pharmacologically inactive risperidone and paliperidone metabolite, 7-hydroxy-risperidone, and does not have substantial cross-reactivity with other pharmacologically inactive risperidone and paliperidone metabolites.
A compound of the formula:
- wherein Y, B, X and p are above;
- wherein B is
- Y is an organic spacing group;
- X is a terminal functional group capable of binding to a carrier;
- and
- p is an integer from 0 to 1.
A conjugate comprising a carrier conjugated with a ligand of the formula:
- wherein B is
- Y is an organic spacing group;
- X is a functional linking group capable of linking to a carrier;
- and
- p is an integer from 0 to 1.
Dependencies are inferred from the claim text.