Suturable Hybrid Superporous Hydrogel Keratoprosthesis for Cornea
AssigneeThe Board of Trustees of the University of Illinois
InventorsMichael Cho, Amelia Zellander
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Abstract
The present invention features a hybrid superporous hydrogel scaffold for cornea regeneration and a method for producing the same. The hybrid hydrogel is composed of a superporous poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The hybrid scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis.
Claims6
A hybrid scaffold for cornea regeneration comprising a superporous hydrogel copolymer, wherein said superporous hydrogel copolymer comprises poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA), and collagen in the pores of said superporous hydrogel copolymer.
A suturable hybrid implant comprising a PHEMA-PMMA copolymer, and collagen in the pores of said PHEMA-PMMA copolymer.
A method for producing a superporous PHEMA-PMMA hydrogel comprising mixing in a solution methylmethacrylate, 2-hydroxyethyl methacrylate, deionized water, pentaerythritol tetraacrylate (PETA), and diemthylformamide (DMF) to form a superporous PHEMA-PMMA hydrogel, wherein DMF promotes dissolution of MMA and HEMA into a gel solution and PETA promotes crosslinking of the PHEMA-PMMA copolymer.
Dependencies are inferred from the claim text.