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US 2012/0071566 A1Published application
Bioabsorbable Polymeric Compositions, Processing Methods, and Medical Devices Therefrom
AssigneeEthicon, Inc.
InventorsBrian M. Kelly, Dennis D. Jamiolkowskii, Christopher DeFelice
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Abstract
Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymers or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Claims114
A bioabsorbable polymer blend, comprising:
- a first bioabsorbable polymer and a second bioabsorbable polymer,
- the first polymer comprising about 76 weight percent to about 92 weight percent of a lactide-rich polymer comprising about 100 mol percent to about 70 mol percent polymerized lactide and about 0 mol percent to about 30 mol percent polymerized glycolide, and the second polymer comprising poly(p-dioxanone),
- wherein the maximum weight percent of poly(p-dioxanone) in the blend is about 24 weight percent and the minimum weight percent of poly(p-dioxanone) in the blend depends upon the molar amount of polymerized lactide in the lactide-rich polymer and is calculated by the expression:
- Weight Percent Poly(p-dioxanone)=(215.6212/Mol Percent Polymerized Lactide)2.7027
- and wherein the polymer blend provides dimensional stability to a manufactured article.
2 more elements
A thermally processed bioabsorbable polymer blend, comprising:
- a first bioabsorbable polymer and a second bioabsorbable polymer,
- the first polymer comprising about 76 weight percent to about 92 weight percent of a lactide-rich polymer comprising about 100 mol percent to about 70 mol percent polymerized lactide and about 0 mol percent to about 30 mol percent polymerized glycolide, and the second polymer comprising poly(p-dioxanone),
- wherein the maximum weight percent of poly(p-dioxanone) in the blend is about 24 weight percent and the minimum weight percent of poly(p-dioxanone) in the blend depends upon the molar amount of polymerized lactide in the lactide-rich polymer and is calculated by the expression:
- Weight Percent Poly(p-dioxanone)=(215.6212/Mol Percent Polymerized Lactide)2.7027
- and wherein the polymer blend provides dimensional stability to a manufactured article.
2 more elements
A bioabsorbable medical device, comprising:
- a medical device having a structure, the medical device comprising a blend of a first bioabsorbable polymer and a second bioabsorbable polymer,
- wherein the first polymer comprises about 76 weight percent to about 92 weight percent of a lactide-rich polymer comprising about 100 mol percent to about 70 mol percent polymerized lactide and about 0 mol percent to about 30 mol percent polymerized glycolide, and the second polymer comprises poly(p-dioxanone),
- wherein the maximum weight percent of poly(p-dioxanone) in the blend is about 24 weight percent and the minimum weight percent of poly(p-dioxanone) in the blend depends upon the molar amount of polymerized lactide in the lactide-rich polymer and is calculated by the expression:
- Weight Percent Poly(p-dioxanone)=(215.6212/Mol Percent Polymerized Lactide)2.7027
- and wherein the polymer blend provides dimensional stability to a manufactured article.
2 more elements
A method of manufacturing a bioabsorbable medical device, comprising the steps of:
- processing a blend of a first bioabsorbable polymer and a second bioabsorbable polymer, the first polymer comprising about 76 weight percent to about 92 weight percent of a lactide-rich polymer comprising about 100 mol percent to about 70 mol percent polymerized lactide and about 0 mol percent to about 30 mol percent polymerized glycolide, and the second polymer comprising poly(p-dioxanone),
- wherein the maximum weight percent of poly(p-dioxanone) in the blend is about 24 weight percent and the minimum weight percent of poly(p-dioxanone) in the blend depends upon the molar amount of polymerized lactide in the lactide-rich polymer and is calculated by the expression:
- Weight Percent Poly(p-dioxanone)=(215.6212/Mol Percent Polymerized Lactide)2.7027
- and forming a bioabsorbable medical device from the blend, wherein the polymer blend provides dimensional stability to the formed device.
1 more element
Dependencies are inferred from the claim text.