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US 2012/0071547 A1Published application
Compounds from soft coral, method of preparation and pharmaceutical uses thereof
AssigneesNational Museum of Marine Biology & Aquarium, National Sun Yat-Sen University
InventorsJYH-HORNG SHEU, WEI-HSIEN WANG, ZHI-HONG WEN, BO-WEI CHEN, PING-JYUN SUNG
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Abstract
The invention relates to compounds from the soft coral and the generation thereof. The invention also relates to the uses of the compounds from the soft coral in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2.
Claims20
A compound represented by the following general formula 1,
- wherein:
- R1 is selected from the group consisting of —H, —OH, —OC(═O)R11, —OOH, and OAc;
- R2 is selected from the group consisting of —S(C═O)CH3 and -OH;
- R3 is selected from the group consisting of —CH3 and —OH;
- R4 is selected from the group consisting of —OH and —OAc;
- R5 is selected from the group consisting of —H, —OAc, and —OC(═O)CH2CH2CH3;
- R6 is selected from the group consisting of —H, —OC(═O)CH2CH2CH3, —OC(═O)CH2CH2S(═O)CH3, and —OAc;
- R7 is selected from the group consisting of —H, —OAc, and ═O;
- R8 is —H;
- R9 is —OC(═O)CH2CH2CH3;
- R10 is —CH3;
- R11 is an alkyl group;
- and
- B is a single bond;
- or
- R1 and R2 together form the group consisting of —O— and a double bond;
- or
- R2 and R3 together form ═CH2;
- or
- R7 and R9 together form —O—;
- or
- R8 and R9 together form a double bond;
- or
- R1 and R9 together form —O—;
- or
- R9 and R10 together form ═CH2;
- or
- R2 and R8 together form a single bond;
- or
- R2 and B together form ═O and R1 and B together form ═O;
- wherein the compound is not the compound represented by the following formula 17 or, 18;
28 more elements
Dependencies are inferred from the claim text.