Novel Glutamic Acid Decarboxylase (GAD) Chimera And Methods Of Use
AssigneeNeurologix, Inc.
InventorsHelen Fitzsimons, Ross Bland
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Abstract
The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain. More specifically, using an adeno-associated viral vector to deliver a nucleotide sequence encoding a novel glutamic acid decarboxylase (GAD) to specific regions of the brain that are over stimulated or disinhibited in various diseases, including neurodegenerative diseases
Claims13
-67. (canceled)
A chimeric nucleic acid comprising a nucleic acid sequence encoding a polypeptide with glutamic acid decarboxylase (GAD) activity having an amino-terminal portion of GAD65 and a carboxy-terminal portion of GAD67, wherein the nucleic acid sequence has a 95% or more identity with SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.